MP3 is lossy, so editing or re-saving it repeatedly degrades the sound. TTA stores audio losslessly in a smaller file than WAV. MP3 is at home in music and podcasts that must play anywhere; TTA is the usual choice for archiving CDs without losing quality. TTA cannot bring back detail that MP3 compression already removed; it simply stores the result without further loss, in a larger file.
The defaults suit most files. Under Options you can trim the start and end.
This pair uses the compatibility engine, ffmpeg built for the browser, because TTA cannot be written by the browser's built-in codecs. It is a one-off download of about 10 MB that the browser keeps, it is slower than the built-in codecs, and it takes files up to 1 GB.